Evaluation of PCR Negativity in Respiratory Specimens of COVID-19 Patients After Hydroxychloroquine and/or Favipiravir Treatment

Objective: We evaluated PCR negativity in oropharyngeal and nasopharyngeal secretions of COVID-19 patients at the end hydroxychloroquine and/or favipiravir treatments. Methods: Study inclusion criteria were being hospitalized, older than 18 years, positivity tested for SARS CoV-2-RNA after treatment. Initially treatment (group 1) was administered to according guide Health Ministry. Favipiravir 2) alone or combination with 3) who unresponsive had severe pneumonia admitted intensive care unit. Control respiratory specimens taken no earlier 24 hours, therapy. Repeated tests 24–48-hour intervals performed still positive test results. The detection made by real-time PCR. Results: study group included 492 received Mean duration symptoms similar among three groups. rate 52.8% hours rates 27.9% (200/492) 48 treatment, %13.8 (123/492) 72nd hour %3.8 (80/492) 96th hour. ratios all specimen days There statistically significant difference between groups time from date determined that early late did not make a terms time. Conclusion: No found receiving